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In March 1945, Chang arrived at the recently founded Worcester Foundation of Experimental Biology in Shrewsbury, Massachusetts, just outside Worcester, on a fellowship granted to him by Gregory Pincus to learn the technique of in vitro fertilisation. It was apparent that they worked well together and Chang would eventually spend the rest of his career at the foundation, researching mammalian fertilisation. Funds became increasingly available for research on reproduction from the 1950s, and the Foundation attracted a number of talented scientists. Chang guided and advised these scientists, may of whom would go on to become leaders in the field of reproduction. While at the Foundation Chang's work contributed to the development of the oral contraceptive, making him one of the co-founders of the combined oral contraceptive pill.cite-ref-natacad-2-5[2]

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